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Endocrine Abstracts

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ea0073oc13.3 | Oral Communications 13: Pituitary and Neuroendocrinology | ECE2021

Cardiovascular and metabolic safety of growth hormone treatment in adult patients with growth hormone deficiency: real-world data from two large studies in the USA and Europe

Charlotte Höybye , Kelepouris Nicky , Nedjatian Navid

IntroductionEvidence suggests that adults with growth hormone deficiency (AGHD) exhibit metabolic abnormalities that are typical of the metabolic syndrome and are risk factors for type 2 diabetes (T2D). Concerns about undesirable effects of growth hormone replacement therapy (GHRT) on glucose metabolism have been raised, but the risk of T2D from AGHD has mixed evidence. This analysis aims to evaluate cardiovascular (CV) and metabolic safety of GHRT in th...
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ea0081ep673 | Pituitary and Neuroendocrinology | ECE2022

Growth hormone (GH) replacement therapy (GHRT) in patients with adult GH deficiency (AGHD) aged ≥60 years: data from NordiNet® IOS and the ANSWER Program

M. Weber Matthias , B. Gordon Murray , Hoybye Charlotte , H. Olsen Anne , Kelepouris Nicky , Nedjatian Navid , M.K. Biller Beverly

Introduction: There are limited data on the effectiveness and safety of GHRT in older patients with AGHD. We compared real-world GHRT outcomes in older (aged ≥60 years) vs middle-aged (35–<60 years) adults.Methods: NordiNet® IOS (NCT00960128) and ANSWER (NCT01009905) were non-interventional studies investigating long-term effectiveness and safety of GHRT with Norditropin® (somatropin, Novo Nordisk). Safety was assessed in the ful...
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ea0073aep4 | Adrenal and Cardiovascular Endocrinology | ECE2021

Biomarkers of cardiovascular disease and inflammation in autoimmune addison’s disease with residual adrenocortical function

Åse Bjorvatn Sævik , Anna-Karin Åkerman , Methlie Paal , Quinkler Marcus , Anders Jørgensen , Charlotte Höybye , Debowska Aleksandra , Bjørn Gunnar Nedrebø , Dahle Anne Lise , Carlsen Siri , Tomkowicz Aneta , Synnøve Holte , Sollid Stina Therese , Nermoen Ingrid , Kaja Grønning , Dahlqvist Per , Grimnes Guri , Skov Jakob , Finnes Trine , Valland Susanna , Wahlberg Jeanette , Simunkova Katerina , Olle Kämpe , Husebye Eystein Sverre , Bensing Sophie , Marianne Øksnes

BackgroundResidual adrenocortical function (RAF) is present in one third of patients with autoimmune Addison’s disease (AAD), yet its clinical significance remains unknown.ObjectiveTo investigate if biomarker profiles of cardiovascular disease and inflammation are different in patients with AAD and RAF compared to patients without RAF and healthy controls.Material and methods<p...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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